Found inside – Page 609Methotrexate nephrotoxicity occurs primarily through the formation of crystals in renal tubules, which causes tubular toxicity and obstruction.33 Because ... Found inside – Page 26Administration of high doses of methotrexate as in the treatment of ALL or osteosarcoma may also result in nephrotoxicity due to the precipitation of ... Found inside – Page 537Cisplatin-induced nephrotoxicity is both cumulative and dose related. ... Methotrexate is not usually nephrotoxic, although 90% of the drug is excreted ... Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Found inside – Page 1165Exacerbation of renal dysfunction can occur with nephrotoxic agents (e.g., ... mesna Appropriate hydration RENAL FAILURE Methotrexate nephrotoxicity occurs ... Found insideUrinary beta2 may be a useful marker of methotrexate nephrotoxicity (62). When serum methotrexate concentrations are high, leucovorin (folinic acid) rescue ... Found inside – Page 48Chabner BA (1996) Concepts in use of high-dose methotrexate therapy: Clin Chem 42 ... J Clin Oncol 9: 670–674 Fox RM (1979) Methotrexate nephrotoxicity. Found inside – Page 216WHAT TO DO: EVALUATE Methotrexate is a widely used therapy in adult and pediatric ... oncology: Understanding and managing methotrexate nephrotoxicity. Found inside – Page 23Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity. Cancer Res Treat. 2005;37(2):133-135. 9. Peyriere H, Cociglio M, ... Found inside – Page 1305Highdose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer. 2004;100(10):2222-2232. Flombaum C, Meyers P. High-dose leucovorin as ... Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Found inside – Page 961Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity. Cancer 1995; 76(3): 521–6. Krackhardt A, Schwartz S, Korfel A, ... Found insideNitrosoureas Streptozotocin is the most nephrotoxic drug in the group of ... Methotrexate may be nephrotoxic when doses higher than 1000 mg/m 2 are used; ... Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Found inside – Page 202At conventional doses, the nephrotoxic potential of methotrexate is very low. However, with the introduction of high-dose therapy of 1–7 g/m with leucovorin ... Found inside – Page 159Methotrexate-induced renal impairment: clinical studies and rescue from systemic toxicity with ... Understanding and managing methotrexate nephrotoxicity. Found inside – Page 317Methotrexate nephrotoxicity can lead to delayed elimination of the drug and the development of life-threatening toxicity. Methotrexate is fully ionized at ... Found inside – Page 380Mitomycin C- induced nephrotoxicity carries significant mortality, with associated pulmonary ... Methotrexate Methotrexate is a widely used anticancer drug. Found inside – Page 13001 * Incomplete urine collection * * Percent of drug excreted as metabolite and may contribute to methotrexate - related nephrotoxicity . However , the precise pharmacological and toxicological significance of this metabolite remains to be ... Found inside – Page 206... management of methotrexate toxicity. J Med Toxicol 2008;4(2):132e40. Widemann BC, Adamson PC. Understanding and managing methotrexate nephrotoxicity. Found inside... 4amino4deoxyN10methylpteroic acid (DAMPA),526 rescues patients who develop methotrexate nephrotoxicity by providing an alternative route of ... Found inside – Page 352Several measures may be used to lessen the incidence of methotrexate nephrotoxicity . First , the concentration of the drug in urine can be decreased by maintaining extracellular fluid volume expansion and a high urine flow rate ( > 100 mL / h ... Found inside – Page 179Difficulty measuring methotrexate in a patient with high-dose methotrexate-induced nephrotoxicity. Clin Chem. 2010;56(12):1792–4. Berg JM, Tymoczko JL, ... Membrane transporters are important determinants of drug disposition and response. Found inside – Page 133The risk of methotrexate nephrotoxicity is reduced greatly by prophylactic intravenous fluid and alkalinization regimens to prevent tubular ... Found inside – Page 824Because of the primary renal rate of excretion and the possibility of nephrotoxicity, methotrexate should be withheld or administered at reduced doses in ... Found insideMethotrexate nephrotoxicity is dose-dependent but usually moderate and reversible.27 In a study28 of 102 patients treated with high-dose methotrexate, ... Found inside – Page 893Methotrexate tends to accumulate in third-space fluids (e.g., ... The risk of methotrexate nephrotoxicity is significantly reduced by ensuring adequate ... Found inside – Page 24The nephrotoxicity of cisplatin is reduced in humans [73], mice [74] and dogs [75] ... In human, methotrexate is largely cleared unchanged from the body by ... Found inside – Page 586In high doses, the drug can be nephrotoxic and cause dermatitis, ... Widemann BC, Adamson PC: Understanding and managing methotrexate nephrotoxicity, ... Found inside – Page 145NEPHROTOXICITY WITH CHEMOTHERAPEUTIC AGENTS Chemotherapeutic agents reported to cause impairment of renal function include cisplatin , methyl CCNU ( 1 , 2 - chlorethyl - 3 , 4 - methylcyclohexyl - 1 - nitrosourea ) , methotrexate ... Found insideHowever, highdose methotrexate regimens (50–250 mg/kg to 1–7 gm/m2) have been associated with a greater incidence of nephrotoxicity [36]. Found inside – Page 2290Methotrexate-Induced Renal Dysfunction Because methotrexate is usually cleared exclusively by the kidneys, nephrotoxicity associated with high-dose ... Found inside – Page 138Nephrotoxicity is not a concern with low or standard dose methotrexate, but at high doses the drug and its metabolites can crystallize in the tubular lumina ... Found inside – Page 299Methotrexate-induced nephrotoxicity is typically an acute treatment side effect and Anthracycline dose Recommended frequency None Every 2 years Any Every ... Found inside – Page 21900 Methotrexate - Procarbazine Significance : 2 — moderately clinically significant Potential Effects : Procarbazine may predispose patients to nephrotoxicity with concurrent methotrexate . Recommendations : Consideration should be given to ... Found inside – Page 1140Nephrotoxicity associated with high-dose methotrexate administration can be considered a true oncologic emergency. Although the strategies of hydration, ... Found inside – Page 783It is postulated that there is some subclinical nephrotoxic effect of indomethicin that inhibits rapid and complete elimination of large methotrexate doses. Found inside – Page 405Thus, methotrexate toxicity may manifest as multiple organ failure [13]. Prevention of nephrotoxicity, together with methotrexate level monitoring, ... Found inside – Page 383Understanding and managing methotrexate nephrotoxicity. Oncologist. 2006;11:694-703. Jacobs SA, Stoller RG, Chabner BA, et al. 7-Hydroxymethotrexate as a ... Found inside – Page 12688Synthesis of the 7 - hydroxy metabolites of methotrexate and Med Pediatr Oncol ... methotrexate nephrotoxicity : nonrenal excretion of serum detection ? Found inside – Page 21... it is unsurprising that other potentially nephrotoxic chemotherapy (e.g. ... information about the frequency of chronic methotrexate nephrotoxicity. Found inside – Page 336... et al : Nephrotoxicity of nitrosoureas . Cancer 48 : 1328 – 1334 , 1981 54 . Hande KR , Donehower RC , Chabner BA : Pharmacology and pharmacokinetics of high - dose methotrexate in man , in Pinedo HM ( ed ) : Clinical Pharmacology of ... Found inside – Page 144Mechanism of Action Methotrexate can be given orally or by injection. ... not associated with nephrotoxicity, unless underlying kidney disease is present. Found inside – Page 301Incidence of drug - related deaths secondary to high - dose methotrexate and citrovorum factor administration . Cancer Treat Rep 1977 ; 61 : 745 – 748 . 130 . Fox RM : Methotrexate nephrotoxicity . Clin Exp Pharmacol Physiol 1979 ; ( suppl ) 5 ... Found inside – Page 119Nitrosoureas Streptozotocin is a highly nephrotoxic drug and could induce ... 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