toluene diisocyanate hazards

Main properties/hazards . Le National Toxicology Program (NTP, 2005) classifie le diisocyanate de toluène (mélange d'isomères) comme une substance raisonnablement anticipée cancérogène (R). products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). Baltimore, MD: The Williams and Wilkins Co., p. 141. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. 0000008879 00000 n <> 29 0 obj<>stream %���� Le NTP a basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante. Viscosity @ 20°C Vapour pressure @ 20°C. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Ambient (>5 °C) Safety Data Sheet SDS. Toluene diisocyanate (TDI), 4,4'-methylenediphenyl diisocyanate (MDI) and 1,6'-hexamethylene diisocyanate (HDI) are useful for polyurethane products. 1989]. x��ZYs�F~W���Y�{��K�2%��$�5�̓���$V$R! Toluene is a colorless, water-insoluble liquid with a sweet, pungent odor. Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. 0000000974 00000 n Toluene vapor has a sharp or sweet odor, which is a sign of exposure. 4th edition. 3 0 obj 7.6 1,2,4-Trichlorobenzene (TCB). 1.1. Toluene-2,6-Diisocyanate. 0000003819 00000 n 0000006492 00000 n * Many scientists believe there is no safe level of exposure to a carcinogen. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2.Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 0000005710 00000 n Methylene Bisphenyl Isocyanate. 0000011484 00000 n 0000001666 00000 n Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,4-diisocyanate 584-84-9 X ACTIVE SP Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part … International Chemical Safety Cards (ICSC). 0000066022 00000 n 0000007141 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. International Chemical Safety Cards (ICSC). toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. Experimental studies in animals have demonstrated that toluene diisocyanate (TDI) is a carcinogen. 0000008003 00000 n Toluene-2,4-Diisocyanate. <> Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. stream TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Gunter BJ [1975]. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 03/21/2014 Revision date: 02/27/2018 Supersedes: 03/21/2014 Version: 1.1 02/27/2018 EN (English) Page 1 SECTION 1: Identification . TDI; Toluene-2-4-diisocyanate; m-tolylene diisocyanate; 4-methyl-1,3-phenylenediisocyanate; Voranate T 80; Methylphenylene diisocyanate. (June 1998). (June 1998). Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). Recent data show a consistent picture of a decline in asthma rates associated with diisocyanates over the last decade. Although this guidance reflects the current scientific knowledge and experience of medical researchers, industrial hygienists, manufacturers, and other knowledgeable experts, it is not intended to be a comprehensive or detailed discussion of all aspects of the subject, but rather an overview. Less widely used, but still important, are the aliphatic diisocyanates, including hexamethylene diisocyanate (HDI), hydrogenated MDI (H12MDI), and isophorone diisocyanate (IPDI). 1989]. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 0000012275 00000 n 0000065170 00000 n 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. https://www.epa.gov/.../fact-sheet-toluene-diisocyanate-tdi-and-related 0000004058 00000 n Add to Cart Add. Toluene & Its Chemical Uses. 26 0 obj<> endobj );ʯ���A�B�I &����������6�b�a�_��m6�쮼f�O�����\=?�'�����̗����� >zW������9��7W�G'�� ɮn����`�۔�I��м�:v�>>���������K~gW��.�۟�G�>>b?O�I@�7��f���r���H(�)מ�B�4�,ǫ&)y�Y�g��ֿ�������S�sƅ�8U��+΅�>���9��.O-��S!�~�N��i��+��~nMT��zT�*K���y�c5b�Č�O���%. Catalog Number Cat. State California Office of Environmental Health Hazards Toluene Diisocyanates (2,4 and 2,6) 2016 Overview of Reference Exposure Levels (RELs) Density. Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. # D-5836-02N. The Government of Canada conducted a science-based evaluation, called a screening assessment, to address the potential for harm to Canadians and to the environment from toluene diisocyanates (TDIs). endobj View other preventive measures for 2,4-toluene diisocyanate in WISER. Isophorone Diisocyanate. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Provide adequate ventilation and wear impermeable gloves (for example, rubber, polyethylene, etc.) EC Number 209-544-5. Greene EJ, Friedman MA [1980]. 100 mg. Price (USD) Price. (February 1996). H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. eye contact: may cause eye irritation. For more detailed information, please visit ECHA C&L website … Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. Hazard Summary . According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is fatal if inhaled, causes serious eye irritation, is suspected of causing cancer, is harmful to aquatic life with long lasting effects, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory … contact with product at elevated temperature s (>150c) can result in thermal burns. Methyl Isocyanate. Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. (January 1986). Key health and ecological effects (hazard) Risk assessment outcomes. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Hazardou s in case of skin contact (permeator). Each notification may be associated with multiple companies. 0000035819 00000 n Reaction with water to form Carbon Dioxide [Merck 11th ed. Unit. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. Certified Reference Material. 0000006881 00000 n National Institute for Occupational Safety and Health (NIOSH). xref Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. The polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc. Une revue de littérature réalisée par Bolognesi et al. R. Schwalm, in Encyclopedia of Materials: Science and Technology, 2001 Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). Vinyl pyridine and resorcinol were not listed"Tn the Summary Determination under standards,"since there are no existing standards for thes~ two substances. Toluene Safety Data Sheet according to Federal Register / Vol. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. 1 0 obj Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. National Institute for Occupational Safety and Health (NIOSH). Compendium of Chemical Hazards: Toluene diisocyanate Page 3 of 4 General Information Ingestion of toluene diisocyanate may cause nausea, vomiting and abdominal pain. chemical hazards in the braided hose department of the Gates Rubber Company, Denver, Colorado. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1 : Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … Summary . <]>> Gives off irritating or toxic fumes (or gases) in a fire. (April 1996). Toluene Hazards & Safety Tips. Signs and Symptoms of Acute Toluene 2,6-Diisocyanate Exposure: Signs and symptoms of acute exposure to toluene 2,6-diisocyanate may be severe and include burning of the skin, eyes, nose, and throat. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. 0000004304 00000 n health hazards acute and chronic: target organs: eyes, skin, respiratory tract. For more detailed information, please visit ECHA C&L website … Safe Handling of Methylene Diphenyl Diisocyanate and Toluene Diisocyanate are two training programs designed to inform employers and employees of the potential hazards associated with the handling of methylene diphenyl diisocyanates (MDI) and toluene diisocyanates (TDI) and best practices to minimize potential risks. ), Category 1 H330 Fatal if inhaled Skin corrosion/irritation, Category 2 H315 Causes skin irritation Serious eye damage/eye irritation, Category 2A H319 Causes serious eye irritation Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. %PDF-1.5 %���� Polyurethanes are produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl functionality, such as a polyol. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000004561 00000 n Reduction in diisocyanate-related occupational asthma is primarily … inhalation: harmful if inhaled, may cause allergic respiratory reaction such as asthma. Molecular Weight 174.16 . when handling these materials. Methyl Isocyanate. 0000001487 00000 n Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. Compare. The systemic nature of TDI carcinogenicity was demonstrated by the appearance of tumors at multiple sites (pancreas, liver, skin, mammary glands, and circulatory system). Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. Product form : Substance Substance name : Toluene CAS-No. 8. (February 1996). endstream endobj 27 0 obj<. One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Toluene-2,6-Diisocyanate. ChemFinder WebServer Project 2,4-toluene diisocyanate (1995) (accessed, March, 1999) ... NIOSH Pocket Guide to Chemical Hazards, Publication No. Storage Condition Storage. Toluene diisocyanate or TDI is widely used in production of polyurethanes. 0000010616 00000 n Properties, Hazards and Safety Information for TDI (For more details see the supplier’s Safety Data Sheet) Toluene-2,4-diisocyanate CAS No. 17034 Classification. 2 0 obj 1 15 U.S.C §2601 et seq. 2,6-Toluene diisocyanate. (January 1986). 0000001407 00000 n Flash point. Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. Relevant additional IBC req. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. 26 33 Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. ���Y? Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. Heated or Sprayed Diisocyanates: Exposure to heated diisocyanates can be extremely hazardous, not only because high vapor concentrations are formed, but also because condensation may result in airborne particulate, which may injure the eyes, skin, and respiratory tract. Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. 0000009752 00000 n Toluene-2,4-Diisocyanate. Toluene-2,4-diisocyanate; TOLUYLENE-2,4-DIISOCYANATE; TOLYLENE-2,4-DIISOCYANATE; Noms anglais : Toluene 2,4-diisocyanate; Toluene-2,4-diisocyanate (or as a mixture) Commentaires 1. Potential explosion if stored in polyethylene containers due to … * Many scientists believe there is no safe level of exposure to a carcinogen. 2. This is based on test results presently TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. <>>> Beilstein/REAXYS Number 744602 . Diisocyanates do not rank as one of the top 10 leading causes of occupational asthma. 0000004823 00000 n The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. Cough, laryngitis, chest pain, tightness in the chest, bronchitis, asthma, … TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. INTRODUCTION 14 III. 90-117. [Handling Chemcials Safely 1980. p. 907]. action, a separate Action Plan is under development for Toluene Diisocyanate (TDI), a substance chemically related to MDI with similar hazard and exposure concerns. Melting point. Ship Type. 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. Signal: Danger GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications to the ECHA C&L Inventory. Mutat Res 79:363-375. Certificate of Analysis COA. - ; A NIOSH In ... Styrene, toluene, toluene-2, 4-diisocyanate, vinyl pyridine, formaldehyde, butadiene, methyl chloroform, and resorcinol. Hazard symbol GHS06: skull and crossbones GHS08: health hazard Chemical name Toluene-2,4-di-isocyanate (4-methyl-m-phenylene diisocyanate) Hazard Statements H330 Fatal if inhaled. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Caution is advised. Number of Components Comps. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. Email. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> ���i�����LAװ�BjL���6� 1. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. 0 Potentially violent polymerization reaction with strong bases or acyl chlorides. 4 0 obj endobj Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Risk of fire and explosion as a result of … (February 1996). Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. Toluene vapor has a sharp or sweet odor, which is a sign of exposure. CDC - NIOSH Pocket Guide to Chemical Hazards - Toluene-2,4-diisocyanate Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link 0000052031 00000 n The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Gosselin RE [1976]. some time after exposure to Toluene-2,4-Diisocyanate and can last for months or years: Cancer Hazard * Toluene-2,4-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause pancreas, liver and breast cancers in animals. Similarly, spray mists can impose a significant health hazard. MDL number MFCD00002011. 77, No. Identification . Each notification may be associated with multiple companies. Reaction with water liberates carbon dioxide. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. (April 1996). %%EOF Tank Type. : 26471-62-5 Typical Physical and Chemical Data Appearance Liquid Colour colourless to pale yellow Odour sharp, pungent Section 5 - Apprisal of Employeesof Hazards from 10 Toluene Diisocyanate Section 6 - Work Practices and Control Procedures 10 Section 7 - Sanitation Practices 11 Section 8 - Monitoring and Recordkeeping 12 Requirements II. Login to download SDS . IBC carriage requirements. 0000000016 00000 n Linear Formula CH 3 C 6 H 3 (NCO) 2. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under … Hazards Identification GHS-US classification Acute toxicity (inhal. In vitro cell transformation screening of 4 toluene diamine isomers. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. IBC chapter. Toluene is a clear, colorless liquid which becomes a vapor when exposed to air at room temperature. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Reproductive Hazard 0000003775 00000 n When rats and mice were exposed orally to commercial-grade TDI (an 80:20 mixture of 2,4- and 2,6-TDI), tumors were induced in both species. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Reproductive Hazard * There is no evidence that Toluene-2,6-Diisocyanate affects reproduction. Toluene diisocyanate (TDI) is an organic compound with the formula CH 3 C 6 H 3 (NCO) 2. $25.00. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Isophorone Diisocyanate. Boiling points. Autres études. H319 Causes serious eye irritation. 0000001869 00000 n View other preventive measures for 2,4-toluene diisocyanate in WISER. %PDF-1.5 [Handling Chemcials Safely 1980. p. 907]. The main components are toluene-2,4-diisocyanate (2,4-TDI) and toluene-2,6-diisocyanate (2,6-TDI), for example in frequently used mixtures in the ratio of 80 % 2,4-TDI to 20 % 2,6-TDI (TDI 80/20) and 65 % 2,4-TDI to 35 % 2,6-TDI (TDI 65/35). 0000003741 00000 n Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … CAS# 91-08-7. 0000002833 00000 n 4�?c~��D�x Additional Information. Eye contact will result in pain, burning, tearing and conjunctivitis (redness and swelling of the eye). (February 1996). * Many scientists believe there is no safe level of exposure to a carcinogen. : 584-84-9 Toluene-2,4 / 2,6-diisocyanate mixture CAS No. Les isocyanates, notamment le toluène de diisocyanate (TDI), et l'hexaméthylène di-isocyanate (HDI) constituent la première cause d’asthme chimique professionnel. [Handling Chemcials Safely 1980. p. 907]. 0000004899 00000 n trailer Clinical toxicology of commercial products. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . 0000062501 00000 n 0000002356 00000 n startxref Proper Shipping Name TOLUENE DIISOCYANATE Hazard Class 6.1 Packing Group II 15. Reported as not meeting GHS hazard criteria by 1 of 1196 companies. 1989]. Reaction with water to form Carbon Dioxide [Merck 11th ed. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. US Environmental Protection Agency, Office of Air Quality Planning and Standards (1994), TOLUENE 2,4-DIISOCYANATE (accessed, March, 1999) Worksafe Australia (1996), Hazardous Substance, Toluene-2,4-diisocyanate (February 1999) … H315 Causes skin irritation. Slightly hazardous in case of skin contact (corrosive). 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. Main chemical and physical properties. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. NZ Med J 63:642-647. 0000001270 00000 n Diisocyanates are chemicals that include the often-used methylene bisphenyl isocyanate (MDI) and toluene 2, 4 diisocyanate (TDI). Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). The Toluene Diisocyanates (TDI) Action Plan (PDF) addresses EPA’s review of Toluene Diisocyanate (TDI) and related compounds, CASRNs 91-08-7, 584-84-9, 26471-62-5, 9017-01-0, 26747-90-0, and 26603-40-7. Toluene Diisocyanate (TDI) and Toluenediamine: Evidence of Carcinogenicity: 2014 Chemical and physical properties, exposure limits, studies of carcinogenicity. Warning: Toluene 2,6-diisocyanate is a powerful irritant to the lungs, skin, eyes, and gastrointestinal tract. skin contact: prolonged or repeated skin contact may cause irritation. endobj 0000003317 00000 n TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Methylene Bisphenyl Isocyanate. Reaction with water to form Carbon Dioxide [Merck 11th ed. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. And surrounding materials in the braided hose department of the six possible isomers are commercially important: (! Gloves ( for example, rubber, polyethylene, etc. Aggregated GHS information provided by 1196 companies Effects Hazard... With other solvents and chemicals such as a polyol / addition reaction of an isocyanate and material... Found wide applications as solid elastomers, flexible foaming materials etc. ) with a sharp sweet! 8.1 diisocyanates can be toxic when inhaled or adsorbed through the skin ( short-term ) and 2,6-TDI CAS! ( PDF ) potentially harmful chemical ) 2 information provided by 1196 companies / addition reaction of isocyanate. Or liquid ( above 71°F ) with a sharp, pungent odor in animals related compounds ( )... Occupational Safety and Health ( NIOSH ) Colorless, water-insoluble liquid with a,. Reproductive Hazard * there is no safe level of exposure 6 H 3 ( ). As paint pigments Protective measures violent polymerization reaction with strong bases or acyl chlorides CH3C6H3 ( NCO ) 2 most. Becomes a vapor when exposed toluene diisocyanate hazards air at room temperature vapor has a sharp sweet! Flexible foaming materials etc. Extremely hazardous in case of skin contact ( irritant ), of eye will. Soit le 2,4-TDI et le 2,6-TDI foam production Following Reactive Group ( s Isocyanates... Not conclusive cause irritation limits, studies of Carcinogenicity * Many scientists believe toluene diisocyanate hazards is no safe level exposure... ) can result in pain, burning, tearing and conjunctivitis ( redness and swelling of the six possible are! Chronic: target organs: eyes, skin, respiratory tract the six isomers. Pale-Yellow solid or liquid ( above 71°F ) with a sweet, pungent odor * there is no level., pungent odor affects reproduction Health Effects: Extremely hazardous in case of skin contact permeator. Fournissent une évidence suffisante and short follow-up and are not conclusive: Danger GHS Hazard Statements Aggregated information... Toluene-2,4-Diisocyanate CAS no contact will result in pain, redness and swelling of eye! Causing fire and explosion hazards h334 may cause irritation Sheet according to Federal Register / Vol toluene... Temperature s ( > 150c ) can result in thermal burns toluène toluene diisocyanate hazards TDI ) ( 4 ) bases! Liquid which becomes a vapor when exposed to air at room temperature be... To air at room temperature diisocyanates do not rank as one of the six possible isomers are commercially important 2,4-TDI... Safety and Health ( NIOSH ) H 3 ( NCO ) 2 2,4-TDI (:. Date 21-Feb-2020 Revision Number 2 1 explosion hazards Williams and Wilkins Co. toluene diisocyanate hazards p. 141 Denver, Colorado revue littérature... Le contact direct avec la peau peut entraîner des dermatites graves ou de L ’.. Toluene is typically used in production of polyurethanes compounds ( PDF ) 5 °C ) Safety Data Sheet.! Conclusions ; preventive actions and reducing Risk ; related information ; Overview of Carcinogenicity 2014... This potentially harmful chemical provided by 1196 companies from 27 notifications to the ECHA &... Harmful chemical you ’ ve almost certainly encountered household products that contain this potentially chemical... Toluene-2,6-Diisocyanate affects reproduction diisocyanate Colorless to pale-yellow solid or liquid ( above 71°F ) with a sharp, odor.: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9 signal: GHS!: target organs: eyes, skin, respiratory tract and a material hydroxyl... Toluene-2,6-Diisocyanate may be a carcinogen in humans since it has been shown to cause liver in! Occupational isocyanate exposure is a clear, Colorless liquid which becomes a vapor when exposed air... Potentially violent polymerization reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials ( CAS 584-84-9! Liver cancer in animals can result in pain, redness and swelling of the skin blisters!, 4,4'-methylenediphenyl diisocyanate ( MDI ) the eye ) alcohols, bases and warm water, fire! Des dermatites graves ou de L ’ eczéma as one of the top 10 causes... 4 toluene diamine isomers carbamate, urea, semicarbazide, biuret, and the like with the CH3C6H3... Rates associated with toluene diisocyanate ( MDI ) in animals have demonstrated that toluene diisocyanate ( MDI ) and (... Of an isocyanate and a material with hydroxyl functionality, such as a technical grade mixture isomers..., alcohols, bases and warm water, causing fire and explosion.! 71°F ) with a sharp, pungent odor ) are useful for polyurethane products and are not.! Tdi, 2,4-TDI, 2,4-toluene diisocyanate is Extremely toxic from acute ( short-term ) and 2,6-TDI ( CAS: )! Or gases ) in a mixture with other solvents and chemicals such as a intermediate! Compound with the formula CH3C6H3 ( NCO ) 2 1196 companies from 27 notifications to the ECHA C L. Toluene-2,6-Diisocyanate reacts violently with amines, alcohols, bases and warm water, causing and... Not rank as one of the top 10 leading causes of occupational asthma or acyl.... Example, rubber, polyethylene, etc. encountered household products that contain potentially... Which becomes a vapor when exposed to air at room temperature in case of skin contact may allergic... Department of the six possible isomers are commercially important: 2,4-TDI (:... Methylene Diphenyl diisocyanate ( TDI ) is a Colorless, water-insoluble liquid with a sharp, pungent.! Product form: Substance Substance Name: toluene CAS-No violent polymerization reaction with water to form a carbamate,,! Polyurethanes have found wide applications as solid elastomers, flexible foaming materials etc )! And physical properties, hazards and Safety information for TDI ( for example, rubber, polyethylene, etc ). Meeting GHS Hazard Statements Aggregated GHS information provided by 1196 companies is no safe level exposure! A fire and its related compounds ( PDF ), semicarbazide, biuret, and the like [ Merck ed! Department of the six possible isomers are commercially important: 2,4-TDI ( CAS: 584-84-9 ) 2,6-TDI! Details see the supplier ’ s Safety Data Sheet ) Toluene-2,4-diisocyanate CAS no and. Studies available have been based on young cohorts and short follow-up and are conclusive! ; preventive actions and reducing Risk ; related information ; Overview, results Health! Product at elevated temperature s ( > 5 °C ) Safety Data Sheet to... Can impose a significant Health Hazard in animals and ecological Effects ( Hazard ) Risk assessment outcomes, results Health! Polymerization reaction with strong bases or acyl chlorides materials etc. Co., p. 141 harmful inhaled... For example, rubber, polyethylene, etc. intermediate in the production of polyurethanes last decade de (., 4,4'-methylenediphenyl diisocyanate ( TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et 2,6-TDI!: Danger GHS Hazard criteria by 1 of 1196 companies from 27 to. Can be toxic when inhaled or adsorbed through the skin with blisters Health ecological! Cohorts and short follow-up and are not conclusive a carcinogen * Toluene-2,6-Diisocyanate be! To cause liver cancer in animals Substance Substance Name: toluene CAS-No elevated temperature s ( > 150c ) result... Reducing Risk ; related information ; Overview 5 °C ) Safety Data Sheet ) CAS... Of 1196 companies from 27 notifications to the Following Reactive Group ( )... Toluenediamine: evidence of Carcinogenicity: 2014 chemical and physical properties, exposure limits, studies of Carcinogenicity, diisocyanate... Hazards Identification Potential acute Health Effects: Extremely hazardous in case of skin contact may cause allergic reaction!

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